A series of new Coumarin - derived Schiff’s base derivatives were synthesized, characterized and screened for their in vitro anti bacterial activity against range of Gram - positive and Gram - negative as well as for their anti fungal activity against a clinical isolate of Candida albicans. The synthesis of Schiff’s bases was carried out by reaction of series of aromatic aldehydes with 8-amino-4-methyl-2h-chromen-2-one (I). Later compound was obtained by the reaction of β – keto ester with 2 – amino phenol by using well known Pechmann condensation using stannous chloride dihydrate as catalyst. All the compounds were characterized with the help of IR and NMR spectroscopy. Compound 2b possess highest anti bacterial activity. While compound 2e possesses highest anti fungal activity.
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